When you run Excel in safe mode, it bypasses functionality and settings such as alternative startup location, changed toolbars, the xlstart folder, and Excel add-ins. You can open Excel in safe mode by pressing and holding Ctrl while you start the program, or by using the /safe switch (excel.exe /safe) when you start the program from the command line. Safe mode lets you start Excel without encountering certain startup programs. Note: If you are having problems opening your Excel files after upgrading from Windows 7 to Windows 10, see Errors opening Office files after upgrading from Windows 7 to Windows 10.